More than 80 private companies employing more than 5.000 workers call the Tri-Cities Research District home. They include some of the largest, research, engineering and construction firms in the world. A growing number of firms provide support services or housing to the area.
- Pacific Northwest National Laboratory – PNNL Master Plan (.pdf)
- MSA (Mission Support Alliance)
- American Electric
- YAHSGS Environmental Solutions
- ToxPredictor
- Innovation Center
- Lockheed Martin
- SIGN (Surgical Implant Generation Network)
- Energy Solutions
- InnovaTek
- IsoRay
